rabbit polyclonal anti fzd7  (Proteintech)

Journal: Oncotarget

Article Title: Sex-specific clinicopathological significance of novel (Frizzled-7) and established (MGMT, IDH1) biomarkers in glioblastoma

doi: 10.18632/oncotarget.10465

Figure Lengend Snippet: A-B. Representative micrographs showing (A) weak, medium or strong expression of FZD7 and (B) heterogenous expression of FZD7 in GBM tissues. Scale bars are indicated in the lower-left corner of each panel. C. FZD7 expression in GBM tissues (n=222) versus non-cancerous brain tissues (brain parenchyma from patients with arteriovenous malformations-AVM; n=52). The medians are shown as black lines and the percentiles (25th and 75th) as vertical boxes with error bars. Statistical analysis was performed with the chi-square test and the p-value is indicated in the upper right corner of the plot. D. Representative micrograph showing FZD7 expression in AVM tissues. The scale bar is indicated in the lower-left corner of the panel. BV= blood vessels; P=brain parenchyma.

Article Snippet: For FZD7 immunohistochemistry, the sections were stained with 2 μg/ml polyclonal rabbit anti-human FZD7 antibodies (Acris Antibodies, Herford, Germany) overnight at 4°C.

Techniques: Expressing

Journal: Oncotarget

Article Title: Sex-specific clinicopathological significance of novel (Frizzled-7) and established (MGMT, IDH1) biomarkers in glioblastoma

doi: 10.18632/oncotarget.10465

Figure Lengend Snippet: A. Kaplan–Meier 5-year survival curves were plotted for the Hannover Cohort 1 patients with low versus high levels of FZD7. Analysis was performed for the entire cohort of patients (all patients), male and female patients, respectively. The log-rank test was used for statistical testing and the p-values are indicated in the upper-right corner of each plot. The numbers of patients per group are indicated next to each curve. B. Multivariate Cox regression analysis models for the Hannover Cohort 1 patients with FZD7 low versus FZD7 high . The models were adjusted for age, Karnofsky scale (KS), therapy and extent of surgical resection, respectively. HR = hazard ratio; 95% CI = 95% confidence interval. C. Kaplan–Meier 2-year survival curves were plotted for the Hannover Cohort 2 patients with low versus high levels of FZD7. The statistical testing was performed as in (A). D. Multivariate Cox regression analysis models for the Hannover Cohort 2 patients with FZD7 low versus FZD7 high . The statistical testing was performed as in (B).

Article Snippet: For FZD7 immunohistochemistry, the sections were stained with 2 μg/ml polyclonal rabbit anti-human FZD7 antibodies (Acris Antibodies, Herford, Germany) overnight at 4°C.

Techniques:

Journal: Oncotarget

Article Title: Sex-specific clinicopathological significance of novel (Frizzled-7) and established (MGMT, IDH1) biomarkers in glioblastoma

doi: 10.18632/oncotarget.10465

Figure Lengend Snippet: A. Kaplan–Meier 5-year survival curves and B. multivariate Cox regression analysis models for the Hannover Cohort 1 patients with FZD7 low MGMT methylated versus FZD7 high MGMT unmethylated phenotypes. C. Kaplan–Meier 5-year survival curves and D. multivariate Cox regression analysis models for the Hannover Cohort 1 patients with FZD7 low IDH1 mutated versus FZD7 high IDH1 wild-type phenotypes. (A, C) Statistical testing was performed with the log-rank test and the p-values are indicated in the upper-right corner of each plot. The numbers of patients per group are indicated next to each curve. (B, D) The multivariate models were adjusted for age, Karnofsky scale (KS), therapy and extent of surgical resection. HR = hazard ratio; 95% CI = 95% confidence interval.

Article Snippet: For FZD7 immunohistochemistry, the sections were stained with 2 μg/ml polyclonal rabbit anti-human FZD7 antibodies (Acris Antibodies, Herford, Germany) overnight at 4°C.

Techniques: Methylation